Structural Biology Center @ Bridge

SBC has successfully revived the QC-Check program for validation of the X-ray and cryo-EM structures. The Quality Control Check was developed at the Joint Center for Structural Genomics. It is maintained by Bridge Structural Biology Center and CARC at USC. GO TO LINK>>

In collaboration with Dr. Yong Zhang at USC, A structure of CD38 in complex with a new ligand was solved at 1.5Å of resolution. The ligand is fully visible with all its details!

In collaboration with Dr. Heinz-Josef Lenz at USC, we have managed to constitute a stable complex of 4 proteins at size of 450Kda for Electron Microscopy. This structure would help us to understand part of the angiogenesis pathways in molecular detail.

In collaboration with Dr. Yong Zhang at USC, A structure of CD38 in complex with a new ligand was solved at 1.65Å of resolution. Ligand has adopted an unpredicted conformation for binding.

Our paper was published at ACS Chemical sciences. PubMed >>

Our paper was accepted at ACS Chemical sciences. This was a collaborative work with TSRI San Diego: "A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure".

Our work has been featured on the cover of the Chemical Science journal, Volume 9, Number 44. MORE >>

Our work has been submitted to Angwante and it is under review. A collaboration with The Scripps Research Institute/San Diego

USC collaboration: Our collaborative paper "Facile chemoenzymatic synthesis of a novel stable mimic of NAD+" was accepted in Chemical Science. S-NAD⁺ is resistant to enzymatic cleavage by human CD38 and sirtuin 2 enzymes, but still able to participate in redox reactions. The structure was solved at 2.4Å at USC structure biology center in collaboration with Dr Yong Zhang at USC. MORE >>

A structure of a protein with a new inhibitor was solved at 2.4Å in collaboration with Dr. Yong Zhang at USC.

Two new structures were solved at 1.4Å and 2.1Å in collaboration with The Scripps Research Institute.

Structure Biology Center starts its activity in its new location and has already received samples on its first day of operation.
The new address: Bridge Institute, Michelson Hall, 1002 West Childs Way, MCB309, Los Angeles, CA, 90089-3502

Structure Biology Center adds more services to help USC labs with molecular Biology and protein expression.

Structure Biology Center is down and is preparing for the move to the new location within USC Campus.

Structure Biology Center will be moving to Michelson hall in December.

A publication in JACS - Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid. MORE>>

A new structure of Escherichia coli chorismate mutase containing a noncanonical amino acid was solved at 2Å in collaboration with The Scripps Research Institute.

A structure of tetrameric form of a 700-residue protein was solved at 3.6Å in collaboration with Dr. Matthew Pratt in at USC.

A structure of native and active APOBEC3A was solved at 2.25Å in collaboration with Dr. Myron Goodman at USC.

The Structure biology center at bridge/USC is online and is operational in beta-testing mode.

• The Structural Biology Center at Bridge will provide you all the necessary means required for structure determination of your protein of interest either soluble or membrane protein.
• SBC@Bridge is a collaborative initiative started by a set of structural biology groups who recently moved to USC and aim to bridge all USC labs to create a more creative, interactive, novel, and productive science at USC Campus.
• Research labs at USC, non-profit research organizations and industrial clients are welcome to use the center.
• Contact us at sbc-bridge-l@maillist.usc.edu

Exploring the potential impact of an expanded genetic code on protein function (Published in PNAS). A collaborative work between TSRI and SBC at Bridge/ USC. MORE>>

Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5 (Published in PlosOne) A collaborative work between USC research lab, Sanford Burnham Institute and SBC at Bridge/ USC. MORE>>

Transition states. Trapping a transition state in a computationally designed protein bottle (Published in Science) A collaborative work between TSRI research lab and SBC at Bridge/ USC. MORE>>